obesitas and sugar disease
Conditions
Interventions
Particicpants will take 2 times a day a capsule of resversatrol (75 mg) or
placebo: 1 during lunch and 1 during the evening meal for a period of 6 months.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Men aged 40-70 years and postmenopausal women aged 50-70 years * BMI: 27-35 kg/m2 * Stable dietary habits: no weight gain or loss > 5kg in the last three months * Willingness to limit consumption of resveratrol-containing food products and willingness to refrain from using resveratrol containing supplements * Subjects will only be included when the dependent medical doctor of this study approves participation after evaluating data obtained during screening
Exclusion criteria
Exclusion criteria: * Uncontrolled hypertension * HbA1c > 6.5% * Previously diagnosed with type 2 diabetes * Medication use known to interfere with glucose homeostasis/metabolism * Current alcohol consumption > 20 grams alcohol/day * Subjects who do not want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study. * Participation in another biomedical study within 1 month before the start of the intervention * Any condition, disease or abnormal laboratory test result that, in the opinion of the Investigator, would interfere with the study outcome, affect trial participation or put the subject at undue risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The most important study parameters are differences in: glucose tolerance, resting energy expenditure, intra-hepatic lipid content, body composition and blood plasma values | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundairy outcome parameters are changes in: blood pressure, muscle strenght, quality of sleep and quality of life | — |
Countries
Netherlands
Outcome results
None listed