auto immune encephalitis inflamed brain
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age of 18 and older. - Status epilepticus or new onset seizures with signs of limbic encephalitis (clinical picture, MRI (FLAIR abnormalities), EEG abnormalities or CSF findings (CSF pleocytosis, increased IgG index, oligoclonal bands) - Patients with acquired chronic focal epilepsy with an unknown cause. - A subgroup of these patients, with chronic focal epilepsy, undergoing epilepsy surgery (without a known underlying cause of their epilepsy or possible (post) encephalitis changes, like mesiotemporal sclerosis and hippocampal sclerosis). These are patients with a pharmacoresistent epilepsy, not responding to first and second-line anti-epileptic drugs.
Exclusion criteria
Exclusion criteria: Patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. characterise new antibody mediated clinical syndromes causing epilepsy. 2. Measure the frequency of every individual antibody mediated syndrome causing epilepsy in adults. 3. Look at outcome of individual antibody mediated syndrome causing epilepsy in adults. | — |
Secondary
| Measure | Time frame |
|---|---|
| - What clinical and epidemiological markers are linked to the specific, individual antibodies? - What markers define poor or good prognosis in adults? | — |
Countries
Netherlands
Outcome results
None listed