autoimmune disorders
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: To be eligible for this trial, children in the study arm must meet all of the following criteria: - Children between 5-17 years born to women with an autoimmune disorder, primarily RA, and prednisone use with a dose * 5mg/day during at least two trimesters of their pregnancy - Parents of the child are able and willing to give written informed consent and comply with the requirements of the study protocol;To be eligible for this trial, children in the control arm must meet all of the following criteria: - Children between 5-17 years born to women with an autoimmune disorder, primarily RA, without prednisone use during their pregnancy - Parents of the child are able and willing to give written informed consent and comply with the requirements of the study protocol
Exclusion criteria
Exclusion criteria: 1) monozygotic twins 2) non-Caucasian children 3) children with congenital abnormalities 4) parental refusal to participate 5) children with hair shorter than 2cm 6) children with chronic illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| I) hair cortisol measurements - proximal 3 cm hair (with about 100 hairs) will be cut from the back of the scalp of the child II) anthropometric data of the child - bloodpressure: 3 times measured on one day - height and weight - waist and hip circumference - fat percentage using a skin fold measured by Holtain caliper III) questionnair: - information on hair, hair products and medication use of the child IV) since the child*s body composition is related to that of its parents, data on height and weight of both parents will be obtained | — |
Secondary
| Measure | Time frame |
|---|---|
| I) DNA analysis in buccal epithelial cells obtained by a mouth swab | — |
Countries
Netherlands
Outcome results
None listed