Unruptured intracranial aneurysm
Conditions
Interventions
Inflammation
Intracranial Aneurysm
Unruptured
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Age * 18 year
 * Presence of an unruptured intracranial aneurysm
 * Standard of care decision to treat the aneurysm
 * The aneurysm is surgically accessible
 * Aneurysm wall sampling is deemed possible by the surgeon
 * Written informed consent is obtained
Exclusion criteria
Exclusion criteria: Technical impairments to perform the study
 * Incapacity to lie in prone position for 60 minutes
 * Aneurysm size smaller than PET detection rate (<7 mm)
 * Physical restrictions, e.g. morbid obesity
 * Claustrophobia
 o Evidence of active infection requiring antibiotic therapy
 o Pregnancy or lactation
 o Renal insufficiency (estimated glomerular filtration rate < 60
 ml/min/1.73 m2)
 o Known allergy to gadolinium contrast agent
 o Patients with pacemakers, defibrillators, other implanted electronic
 devices, or possible metal particles
 o Treatment with metformin
 o Multiple myeloma (Kahlers disease)
 o Waldenstrom macroglobulinemia
 o Myasthenia gravis
 o Pheochromocytoma
 o Mastocytosis
 o Thyroid cancer
 o Planned thyroid scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of inflammation by 18F-IL2 PET, related to the gold standard (histopathology/molecular analysis). | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of interobserver variability in 18F-IL2 PET interpretation. | — |
Countries
The Netherlands
Outcome results
None listed