alcohol dependence alcohol addiction and alcohol dependence
Conditions
Interventions
ABM Training
Each participant will be randomly assigned to one of two ABM training groups
based on the work by Kruijt et al (2013):
(1) Control-training group (Participants will be trained on an
alc
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male and female alcohol dependent out-patients, aged between 18-70 years * Current DSM-V diagnosis of alcohol dependence * Right-handed. * Within the normal BMI range (18-30). * Able to speak and understand Dutch. * Able to speak and understand English.
Exclusion criteria
Exclusion criteria: * Impairments in visual processing or in hand-eye coordination (this would make it difficult for patients to perform properly in the scanner) * Being on anticraving medication (naltrexon, campral of baclofen). * No previous or current abuse of drugs other than alcohol (excluding nicotine, cannabis and caffeine) * Pregnancy, trying to conceive or breastfeeding. * Having any metal implants, working or having worked with metal, teeth braces or bridges, tattoos above the shoulder, or cardiac pacemaker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be the number of alcohol-containing drinks a patient drank during the training period and during the month after the end of the training. This will be assessed using a questionnaire-based self-report measure. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will use two cognitive tasks in the MRI scanner and collect BOLD response data in the presence of stimuli associated with alcohol, relative to stimuli not-associated with alcohol in both tasks: In the Concurrent Flanker/Alcohol-attentional bias task (CFAAT; Nikolaou et al., 2012; 2013), the Eriksen Flanker task is superimposed on backgrounds of alcohol-related or neutral pictures. Participants respond to the direction of a central *target* arrow and ignore adjacent congruent or incongruent flanking-arrows, in the presence of task-unrelated neutral or alcohol-associated pictures. 20 alcohol-related and 20 neutral grey-scaled pictures will be used. Each picture will be presented with each possible flanker arrow presentation (i.e. arrows congruent pointing left; incongruent pointing left; congruent pointing right; incongruent pointing right). 80 filler trials, in which the task is performed in the absence of the background pictures, will also be included in order to reduce habituation with the background pictures. Images will be presented in a pseudorandom order so that the same flanker condition and the same background condition will not be presented on more than three consecutive trials. Each trial begins with the presentation of a central fixation cross of varied duration (850-1150ms). The fixation cross is replaced by the stimulus-display which is presented for 500ms, and consists of the centrally-presented row of *target* and *flanking* arrows superimposed on the task-unrelated background displays. Each trial terminates when the response interval ends. Total task duration is 9 minutes. This task measures attentional biases to alcohol-related stimuli under conditions in which cognitive/attentional load is manipulated. The Alcohol-related cue reactivity task is an event related task that involves the presentation of 30 alcohol-related, 30 neutral and 10 target grey-scaled images one at a time. Participants will be told to pay careful att | — |
Countries
Netherlands
Outcome results
None listed