Microvasculair function the function of the smaller cardiac blood vessels
Conditions
Interventions
Sponsors
Cardiologie
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Index group: asymptomatic athletes with concordant abnormal exercise electrocardiography results and abnormal myocardial perfusion scintigraphy results but without the presence of epicardial coronary artery disease. ;An athlete is defined as a sportsmen who is engaged in sports for at least 2.5 hours a week for a period of minimally 30 weeks per year or in two or more sports with a minimum of 1.5 hours per week within one type of sports for at least 20 weeks per year;Control group: Individuals with a low a priori risk of CAD and without presence of significant epicardial coronary artery disease who last year already have undergone PET/CT as part of a prior diagnostic procedure.
Exclusion criteria
Exclusion criteria: Symptomatic athletes ((Exercise induced) chest pain, palpitations, dizziness, light headiness or syncope), athletes with epicardial coronary artery disease, athletes with previous myocardial infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Myocardial blood flow (MBF) per gram of myocardial tissue (ml/min/g) with 82Rb PET-CT imaging. * Myocardial flow reserve (MBF at peak hyperaemia / MBF at rest) with 82Rb PET-CT imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| * The plasma levels of eNOS and ET-1 in athletes with a normal and abnormal exercise test result. | — |
Countries
The Netherlands
Outcome results
None listed