The extent and time-frame of endogenous inhibitory effects after a cold pressor test using a conditioned pain modulation paradigm (ICE study)

The extent and time-frame of endogenous inhibitory effects after a cold pressor test using a conditioned pain modulation paradigm (ICE study) - NAP study substudy: ICE study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON44617

Enrollment

Registered

2014-09-03

Start date

2015-01-22

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pijn systeem, onder andere tijdens slaapdeprivatie pain thresholds before and after a cold pressor test

Interventions

-2 test sessions

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Healthy male subjects • Age 25-35 years • Resident in Anesthesiology, Cardiology, Surgery, Internal Medicine, Orthopedics, Urology, Emergency Medicine. • Ability to obtain informed consent • Subject speaks Dutch • Willingness to comply with study protocol

Exclusion criteria

Exclusion criteria: • Use of analgetics • History of psychiatric or neurological disease • Chronic pain disorders • Diabetes Mellitus • Systemic illness • (History of) substance abuse (drugs, alcohol) • Kidney disease • Disorders revealed during brief neurological examination • Dermal lesions at the site of stimulation (i.e. psoriasis, ulcera, infection) • Pregnancy or breast feeding • Subject currently has an active implantable device including ICD/pacemaker • Exams/board reviews or other educational related obligations in the week of study sessions. • Transmeridian travel within 1 month before the study

Design outcomes

Primary

Measure	Time frame
Electrical Pain Detection Threshold (EPDT) EPDT (mA) (baseline) EPDT (mA) (NRS=0, 6, 10) EPDT (mA) (t = +1, 5, 10, 15min) Pressure Pain Detection Threshold (N) Cold Pressor Test: CPT (sec) (baseline) CPT (sec) (NRS=0, 6, 10) CPM (% EPDT) (NRS=0, 6, 10) CPM (% EPDT) (t = +1, 5, 10, 15min))	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)