chronic systolic heart failure heart failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: Patients (18-85 years) with chronic systolic heart failure NYHA II-III that have been admitted to the UMC Utrecht;Controls: Patients (18-85 years) that have been admitted to the hospital
Exclusion criteria
Exclusion criteria: Patients: -Blindness -End stage renal failure (GFR 38C -CRP >20mg/L -Use of hypnotics or other medication that disturbs the normal sleep pattern during study period -Anaesthesia within 48 hours prior to start study -Serious comorbidity that prevents participation according to the investigators (e.g. severe neurological, psychiatric, or oncologic diseases);Controls: - Blindness - Fever >38C - CRP >20mg/L - Use of hypnotics or other medication that disturbs the normal sleep pattern during study period - Anesthesia within 48 hours prior to start study - Serious comorbidity that prevents participation according to the investigators (including heart and kidney failure)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circadian expression profile of clock (controlled) genes in the blood, e.g. BMAL 1 (Brain and muscle aryl hydrocarbon receptor nuclear trans locator (ARNT~}like protein -1, CRY1 (Cryptochrome protein 1 ), PER2 (Period circadian protein homolog 2), PER3 (Period circadian protein homolog 3), REV-ERBa, DBP (Albumin D-box binding protein). | — |
Secondary
| Measure | Time frame |
|---|---|
| Daytime sleepiness (Epworth Sleepiness Scale) Chronotype (Chronotype questionnaire) Medication (Medication record) Food + coffee intake 24h blood pressure profile 24h activity profile (actometer) 24h cardiac electrical activity (ECG) profile | — |
Countries
Netherlands
Outcome results
None listed