voedingsfysiologie in gezonde personen protein absorption protein digestion
Conditions
Interventions
Single consumption of 6 different dairy products, depending on the study group,
on 6 separate test days, in a portion size that contains 25 g of protein.
Sponsors
FrieslandCampina Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18-65y - BMI 18,5-30 kg/m2 - Non-smoking - Healthy as assessed by the NIZO lifestyle and health questionnaire ("Verklaring leefgewoonten en gezondheid") and according to the judgment of the study physician. - Regular and normal Dutch eating habits as assessed by the NIZO lifestyle and health questionnaire (3 main meals per day) - Veins suitable for cannulation (blood sampling) - Voluntary participation - Having given written informed consent - Willing to comply with study procedures - Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years. - Accept disclosure of the financial benefit of participation in the study to the authorities concerned
Exclusion criteria
Exclusion criteria: - Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study - Having a history of medical or surgical events that may significantly affect the study outcome, including: Inflammatory bowel disease, hepatitis, pancreatitis, ulcers, gastrointestinal or rectal bleeding; major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; known or suspected gastrointestinal disorders, colon or GI tract cancer - Use of the following medication: glucose lowering drugs, insulin; medication that may impact gastric emptying (e.g. gastric acid inhibitors or laxatives) - Diagnosed with diabetes, being treated for high blood glucose or increased fasting blood glucose (> 7 mmol/l in finger prick blood) as assessed during screening visit - For men: Hb 28 units/week and 4/day - Reported unexplained weight loss or weight gain of > 3 kg in the month prior to pre-study screening, or intention to lose weight during the study period - Reported slimming or medically prescribed diet - Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma amino acid concentrations before and at 13 time points (up till 5 hours) after consumption of the dairy products | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed