Neural development of spatial cognition: an fMRI study on the effects of current and past nutritional status

Neural development of spatial cognition: an fMRI study on the effects of current and past nutritional status - Nutrition & Spatial cognition

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44559

Enrollment

Registered

2018-05-22

Start date

2018-12-12

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde proefpersonen, eventueel met overgewicht not applicable

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Age: 8-10 Healthy fMRI compatible Proficient use of Dutch in both child and parent

Exclusion criteria

Exclusion criteria: - Deafness, blindness, or sensori-motor handicaps - Neuropsychiatric disorders - Diabetes - Chronic inflammatory diseases - Daily use of ibuprofen, aspirin or glucocorticoids - Any recent tooth extraction one month prior to the experiment - History of oral candidiasis - Acute illness with fever, vomiting, or diarrhea within 5 days of the study - Recent use of antibiotics (within 3 months prior to the experiment);Exclusion criteria for MRI: - Non-removable metal in the upper body - Active implant, pacemaker, neurostimulator, insulin pump and/or auditory prosthetic - Epilepsy - Claustrophobia - Brain surgery in the anamnesis

Design outcomes

Primary

Measure	Time frame
Differences in brain activation patterns (fMRI) pre- and post-training are the main outcome measures for this study. These will be related to nutritional status, as measured by a composite score of the Dutch healthy diet index (i.e. a food frequency questionnaire assessing adherence to the Dutch healthy diet guidelines) and visceral adipose tissue quantified by abdominal MRI.	—

Secondary

Measure	Time frame
In secondary analyses, we want to see how inflammatory markers, DNA methylation (LY86 gene) (both measured from saliva) and gut microbiome diversity (measured from stool) relate to the neurocognitive development of spatial cognition, as potential mediators of the primary effects. We will also decompose the composite score based on the FFQ and visceral adipose tissue to explore whether sub-components are driving the effects. As motivation for food reward and executive functioning have been clearly related to obesity in previous studies with children, we will include behavioural measures of these as a positive control (using the Progressive Ratio task and Flanker task respectively).	—

Measure

Time frame

In secondary analyses, we want to see how inflammatory markers, DNA methylation (LY86 gene) (both measured from saliva) and gut microbiome diversity (measured from stool) relate to the neurocognitive development of spatial cognition, as potential mediators of the primary effects. We will also decompose the composite score based on the FFQ and visceral adipose tissue to explore whether sub-components are driving the effects. As motivation for food reward and executive functioning have been clearly related to obesity in previous studies with children, we will include behavioural measures of these as a positive control (using the Progressive Ratio task and Flanker task respectively).

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Countries

Netherlands

Outcome results