Language development problems
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: - Age 6-10 years old - A diagnosis of Specific Language Impairment (SLI) or 22q11DS
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Metal objects in the body that are not MRI compatible - Anxiety in the scanner (evaluated by parent/caretaker, or after practice in mock scanner) - Both verbal and non-verbal IQ lower than 70 - Severe hearing loss (>35 dB) - Relevant comorbidities (i.e. severe autism) Notably, to determine the last three parameters, the respective physician/hospital or school/institution will be asked to provide the researchers with neuropsychological/IQ test results, the results of hearing tests and relevant comorbidities. Parents/caretakers of participants will be asked for permission for this during one of the phone calls in the recruitment phase. To confirm current hearing ability, during the first visit, a tone audiogram will be made. If a recent (i.e. less than 2 years old) IQ test is not available, a new IQ test will be administered.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Similarity between 22q11DS and SLI language activation patterns and that of a healthy control population. In other words: do the children with 22Q11DS and SLI show fMRI language-activation in the same brain regions as controls? | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between language activation parameters (e.g. language lateralization index, amplitude of signal changes in the language areas) and scores on language tasks of the children with language impairment. | — |
Countries
Netherlands
Outcome results
None listed