The effect of cold exposure on influenza induced immune responses

The effect of cold exposure on influenza induced immune responses - Influence cold

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON44547

Enrollment

175

Registered

2017-08-03

Start date

2017-08-18

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

common cold flu Influenza viral infection

Interventions

all participants exposed to a cold water bath. Before and after cold exposure blood will be drawn to analyze changes in immune responses.

Cold

Immune response

Influenza

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy Older than 18 years of age Written Informed consent

Exclusion criteria

Exclusion criteria: Medical history associated with immunodeficicency, cardiovascular events or cardiac rhythm disorders or chronic diseases. Chronic use of immunosuppressives or NSAID's, acute illness within 2 weeks prior to start of the study. Substance abuse defined as drug use within the last 12 hours or blood alcohol percentage above 0.05

Design outcomes

Primary

Measure	Time frame
comparison of cytokine responses after ex-vivo whole blood stimulations before and after cold exposure.	—

Secondary

Measure	Time frame
Compare complete blood counts before and after cold exposure	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)