The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis

The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis - VitD-EX

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON44546

Enrollment

288

Registered

2014-02-24

Start date

2014-09-30

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

arthrosis deformans cartilage wear

Interventions

The total intervention period will be 6 months. In the first 3 months, vitamin D tablets (1200IU daily) or placebo tablets will be taken in order to increase the 25(OH) vitamin D level (in case of v

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Knee pain and at least 2 of the following 5 items: morning stiffness = 55 and 15nmol/L and

Exclusion criteria

Exclusion criteria: - Other forms of arthritis than OA - Absolute contra-indication for exercise therapy/strength training - Inability to perform strength training program due to severe comorbidity - Use of vitamin D supplements >800 IU daily - Living in a nursing home

Design outcomes

Primary

Measure	Time frame
Muscle strength of quadriceps and hamstrings (isokinetic test)	—

Secondary

Measure	Time frame
Knee pain, activity limitations (self-reported and performance-based), knee instability/falls and fractures (self-reported), proprioception (test), inflammatory factors in blood, and depressive and anxious mood (self-reported). Global perceived effect.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)