hypercoagulability thrombosis
Conditions
Interventions
N.A.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy subjects (without any morbidity and witbout obvious signs of illness, not taking any medication interfering with coagulation), willing to participate in bot parts of our study All healthy volunteers will undergo a physical check-up by a medical doctor. During this check-up, the medical doctor will look at the ECG, measure blood pressure, heart rate and blood oxygen level. Subjects must be between 18 and 50 years of age. This maximum age is taken to prevent comorbodities that may influence coagulation (such as diabates, atherosclerosis, peripheral arterial disease).
Exclusion criteria
Exclusion criteria: Use of medication interfering with blood coagulation (such as vitamin K antagonists, new oral anticoagulants, low molecular weight heparins). Presence of cardiovascular disease of any other serious comorbidity. Age below 18 of above 50 years old. Not passing physical check-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole blood will be used for measuring thrombin generation, platelet function test, measuring phospholipid exposition on the cellular membranes and for a whole blood count (Hb, Ht, number of red blood cells, number of leucocytes, number of platelets). The whole blood thrombin generation samples will be fixated for studying blood cell morphology using scanning electron microscopy. Plasma will be used for measuring thrombin generation, routine coagulation tests and for quantifying microparticles. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed