Effect of perioperative ketamine on postoperative cognition * a randomized placebo-controlled trial

Effect of perioperative ketamine on postoperative cognition * a randomized placebo-controlled trial - Proket study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON44544

Enrollment

Registered

2014-03-20

Start date

2014-09-17

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperatieve cognitie postoperative cognitive dysfunction

Interventions

Infusion of s-ketamine

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients planned for elective surgery lasting > 1 h that require postoperative pain relief will be enrolled in the study after written informed consent is obtained.

Exclusion criteria

Exclusion criteria: * age 35 kg/m2, * history or present psychiatric disease, * untreated/uncontrolled hypertension (with a diastolic blood pressure > 100 mmHg), epilepsy, * increased intracranial pressure, * untreated hypertension, * untreated ischemic cardiac disease, * inability to communicate in the Dutch language, * inability to give informed consent. * Known liver disease * inability to wear the RespiR8 mask

Design outcomes

Primary

Measure	Time frame
Cognition assessment accoring to the dual task test, the NeuroCart battery and the MiniMental State Examination.	—

Secondary

Measure	Time frame
Pain relief/chronic pain development at 30 days Effect breathing frequency on cognitive function	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)