Stress, habits and attachment in obsessive-compulsive disorder

Stress, habits and attachment in obsessive-compulsive disorder - Stress, habits and attachment in OCD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44537

Enrollment

Registered

2014-08-22

Start date

2016-01-25

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Compulsive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: - Diagnosis of OCD with obsessions and compulsions assessed with the MINI Neuropsychiatric Interview (MINI) - Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12 - 18-65 years of age - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements;Controls: - 18-65 years of age - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

Exclusion criteria

Exclusion criteria: Patients: - Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI - Major head trauma or neurological disease, current or in history - MRI contraindications such as metal implants, claustrophobia, pregnancy - Self-reported inability or unease to cease smoking for 3 hours prior to testing - Endocrinological disorders or regular use of corticosteroids - Current treatment with antipsychotic medication - Use of other psychotropic medication (apart from SSRI's and tricyclic antidepressants), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement - Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).;Controls: - A current or past psychiatric diagnosis as assessed with the MINI - Major head trauma or neurological disease, current or in history - MRI contraindications such as metal implants, claustrophobia , pregnancy - Self-reported inability or unease to cease smoking for 3 hours prior to testing - Endocrinological disorders or regular use of corticosteroids - Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement - Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel)

Design outcomes

Primary

Measure	Time frame
Our main study endpoints include 1.) The balance between goal-directed and habitual responding as measured by the appetitive and avoidance habit task; 2.) The amount of compulsive checking behavior and experienced intolerance of uncertainty as measured in the checking task; 3.) Brain activation patterns as measured with fMRI during these tasks, and an additional emotional face matching task, resting-state condition and DTI; and 4.) The correlation between attachment style as measured with the AAI and ERC with the behavorial and neurobiological study end points of 1-3.	—

Measure

Time frame

Our main study endpoints include 1.) The balance between goal-directed and habitual responding as measured by the appetitive and avoidance habit task; 2.) The amount of compulsive checking behavior and experienced intolerance of uncertainty as measured in the checking task; 3.) Brain activation patterns as measured with fMRI during these tasks, and an additional emotional face matching task, resting-state condition and DTI; and 4.) The correlation between attachment style as measured with the AAI and ERC with the behavorial and neurobiological study end points of 1-3.

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Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results