obesitas obesity
Conditions
Interventions
early life stress
maternal anxiety
obesity
trauma
Sponsors
AMC
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: The ABCD- study cohort consists of 12-13 year old children whose mothers have been participating in the ABCD-study since the start of antenatal care during pregnancy. For the present study a subsample will be selected consisting of: • Children whose mothers scored in the 90st percentile of the State trait Anxiety Inventory during pregnancy (n=30) • Children whose mothers were in the 90st percentile of BMI before pregnancy (n=30) • Children who scored above the clinical cut-off score on the Children*s Revised Impact of Event Scale (CRIES) at the age of 11-12 years (n=30). • A control group of children who do not fulfil the above criteria (n=30).
Exclusion criteria
Exclusion criteria: Children born to mothers who did not participate in the ABCD-study during phase 1. Additionally, of the children born to mothers who did participate in the ABCD-study, all multiples and those whose parents did not give informed consent for the health check will be excluded. Additionally those children who do not give consent will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measures per key objective 1. Caloric intake: calculated from Food Frequency Questionnaire. 2. a. Neural cognitive control over food intake: we will compare fMRI responses to a food-based Go-No-Go test to measure impulsivity. b. Neural food reward responsiveness: we will compare fMRI responses between exposure groups in response to receiving cholate milk versus a tasteless solution. c. Satiety: satiety responsiveness based on Child Eating Behaviour Questionnaire (CEBQ); leptin and ghrelin levels to be assessed from saliva samples . d. Emotional eating: quantity of food intake in response to stresstask during fMRI protocol; Dutch Eating Behaviour Questionnaire. Perceived stress: in response to stress and based on Perceived Stress Questionnaire. e. Food preference: food cue responsiveness based on CEBQ . f. Cortisol activity: cortisol day curves from saliva (4 samples) and in response to stresstask during fMRI protocol (4 saliva samples); cortisol from hair sample (to measure stress over longer period of time). 3. Mental health: total score on Strengths and Difficulties Questionnaire (SDQ) and on Children*s Revised Impact of Event Scale (CRIES-13) administered at 11-12. | — |
Secondary
| Measure | Time frame |
|---|---|
| Covariates/confounders: maternal characteristics, birth outcomes, socio-economic status, ethnicity, physical activity, sedentary behaviour and sleep. | — |
Countries
The Netherlands
Outcome results
None listed