Improved diagnosis for patients with immune-mediated neuropathies

Improved diagnosis for patients with immune-mediated neuropathies - INTEND

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44505

Enrollment

Registered

2014-03-31

Start date

2014-05-20

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neuromuscular disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Signs and symptoms consistent with Multifocal Motor Neuropathy, Chronic inflammatory demyelinating polyneuropathy or Focal/monomelic Spinal Muscular Atrophy;* Adult (*18 years ) * Fulfilling the EFNS/PNS criteria

Exclusion criteria

Exclusion criteria: * Subject is unwilling or unable to participate in this study and to give informed consent. * Legally incompetent adult * Use of drugs which are known to cause motor neuropathy * Other diseases known to cause neuropathy or to reduce mobility * Diseases known to lead to severe handicap or death at short notice * Subject has a prosthesis which is not verifiable MR-compatible by registration number. * Contraindications to undergo a MRI scan (I.e. pregnancy, claustrophobia, metal corpora aliena or metal implants such as pacemakers).

Design outcomes

Primary

Measure	Time frame
Correlation between MRI, US, NCS, muscle strength, disability scale.	—

Secondary

Measure	Time frame
1. NCS outcome (EFNS/PNS guideline) a. Temporal dispersion, Conduction velocity, conduction block 2. US a. Cross sectional area b. Vascularization c. Echo intensity 3. MRI a. Diameters b. Scoring of hyperintensities and swelling c. DTI parameters and architecture of affected nerves and muscles 4. Muscle strength * hand-held dynamometry and MRC scores 5. Overall Neuropathy Limitations Scale (ONLS) 6. INCAT sensory Scale (ISS)	—

Measure

Time frame

1. NCS outcome (EFNS/PNS guideline) a. Temporal dispersion, Conduction velocity, conduction block 2. US a. Cross sectional area b. Vascularization c. Echo intensity 3. MRI a. Diameters b. Scoring of hyperintensities and swelling c. DTI parameters and architecture of affected nerves and muscles 4. Muscle strength * hand-held dynamometry and MRC scores 5. Overall Neuropathy Limitations Scale (ONLS) 6. INCAT sensory Scale (ISS)

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Countries

Netherlands

Outcome results