effecten van stress op connectiviteit van het brein Stress-related psychiatric disorders
Conditions
Interventions
Participants are randomized to either a stress test or a control test.
o Stress: the Trier Social Stress Test (TSST), a validated and standardized
test to induce psychosocial stress in laboratory set
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 18 and 55 years old - 1st degree family member with schizophrenia (unaffected sibling group only)
Exclusion criteria
Exclusion criteria: General exclusion criteria: - Incapability of giving informed consent - Lack of fluency in the Dutch language or speech impairments - Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel). - Use of medication which might influence the stress response, such as psychotropics, beta blockers, ACE inhibitors and any hormonal treatment. - Major medical history including history of closed or open head injury. - Acute minor medical illness within the three weeks prior to testing - Current psychiatric, neurological or endocrine disorder including claustrophobia and alcohol abuse or dependence - Epilepsy in 1st degree family - Psychiatric illness in 1st degree family (only in healthy control group) - Self-reported current or past drug use in the last 2 weeks - Ferrous objects in or around the body according to default checklist present ;Acute exclusion criteria: - Any acute inflammatory disease - Physical exertion within the last 2 hours - Drink other than water or any food within the last 2 hours - Any alcohol use in the last 24 hours - Positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine and opiates)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Task-induced and resting state functional connectivity between the prefrontal cortex and amygdala | — |
Secondary
| Measure | Time frame |
|---|---|
| - Basal and stress-induced levels of cortisol, alpha amylase, heart rate and perceived stress levels. - (Epi)genetic variation in a limited number of stress genes. | — |
Countries
Netherlands
Outcome results
None listed