ICU acquired weakness critical illness polyneuropathy nerve damage as a result of critical illness
Conditions
Interventions
NMES twice a day, for 2 days
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - older than 18 years - sedated (all levels of sedation) or not yet responsive (Ramsay 5-6) - Volume supported or pressure supported mechanically ventilated - respiratory and hemodynamically stable - signed formed consent by legal representative
Exclusion criteria
Exclusion criteria: - known systemic neuromuscular disease (eg, Guillain-Barre syndrome) - ability to actively move the legs - life expectancy less than 24 hours determined by the physician - in contact isolation - pacemaker or implanted cardiac defibrillator - pregnancy - body mass index of > 35kg/m2 - condition in the lower extremity preventing treatment (Skin lesions, fractures, amputations, known or suspected malignancy in the legs, myopathy, paresis of the stimulated muscles, epilepsy, allergic reactions to the electrodes, peripheral edemas counteracting NMES, heavy ischaemia of the lower extremities - corticosteroids usage (>7.5mg/day >3 months) - positive end-expiratory pressure (PEEP) > 14 cmH2O, Fraction of inspired oxygen (FiO2) >0.6 and the presence of air leakage (Haugen, Chan, & Li, 2007) (Kho et al., 2012, Gruther et al., 2010). - patients that receive therapeutic hypothermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effects of NMES on energy expenditure | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effects of NMES on: - Muscle contraction size as indication of muscle fatigue - Hemodynamics: Blood pressure and heart rate measured continuously - Breathing frequency To evaluate the effects of NMES on safety parameters: - Presence or development of metabolic acidosis (pH | — |
Countries
Netherlands
Outcome results
None listed