Thyroid hormone metabolism and innate immunity: the role of deiodinase type 3 in polymorphonuclear leukocytes

Thyroid hormone metabolism and innate immunity: the role of deiodinase type 3 in polymorphonuclear leukocytes - The role of deiodinase type 3 in polymorphonuclear leukocytes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44488

Enrollment

Registered

2014-05-05

Start date

2014-05-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Leukocyte function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers: 1. Aged >=18 2. Willing and able to provide signed informed consent prior to study-related procedures.

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:;1. History of haematological diseases 2. Fever or other symptoms of infection during the past 7 days. 3. Use of medication that could affect haematological parameters or neutrophil function as specified by the Farmacotherapeutisch Kompas (http://www.fk.cvz.nl)

Design outcomes

Primary

Measure	Time frame
The main study parameters are changes in the amount of D3 protein, D3 activity, bacterial killing capacity and subcellular localisation of D3 in activated versus non-activated leukocytes.	—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results