cardiovascular disease cardiovascular risk
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: - Age * 65 years - Available informant - * two cardiovascular risk factors and/or manifest cardiovascular disease defined as: cardiovascular risk factors; * hypertension, defined by either: o diagnosis by specialist or a general practicioner o currently on anti-hypertensive drugs o if 30 o Waist circumference men >102 cm, women >88 cm * active smoking (self-reported, any tobacco use) * lack of physical exercise (self-reported) defined as below the WHO norm of 5 times a week 30 minutes (or a total of 150 minutes per week) of intermediate exercise. OR * History of cardiovascular disease: stroke/TIA, myocardial infarction, angina pectoris, peripheral arterial disease and/or diabetes mellitus (DM)
Exclusion criteria
Exclusion criteria: - Previously diagnosed dementia as diagnosed by a GP or specialist - Mini Mental State Examination score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is a weighted composite score based on z-scores of the difference between baseline and 18 months follow-up values of systolic blood pressure, cholesterol and BMI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Main secondary endpoints are z-scores of the individual risk factors, 10-year risk of cardiovascular disease (Framingham risk score), number of risk factors on target, incident cardiovascular disease, CAIDE dementia risk-score, disability, depression, cognitive decline and mortality. | — |
Countries
Netherlands