The Relationship between Atrial SEptal Defects (ASD) And BRonChial Hyperresponsiveness (SEARCH); Towards understanding the mechanism of dyspnea in adult ASD patients.

The Relationship between Atrial SEptal Defects (ASD) And BRonChial Hyperresponsiveness (SEARCH); Towards understanding the mechanism of dyspnea in adult ASD patients. - SEARCH

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44433

Enrollment

Registered

2017-10-05

Start date

2017-10-06

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

airway hyperresponsiveness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: *Adult age (> 18 years) *Secundum ASD successfully closed using a septal occluder *Available spirometry and methacholine provocation test results from before percutaneous ASD closure.

Exclusion criteria

Exclusion criteria: Absolute contraindications o Severe airflow limitation (FEV1 200mmHg or diastolic BP >100mmHg) Relative contraindications: o Moderate airflow limitation (FEV1

Design outcomes

Primary

Measure	Time frame
Primary ~: presence and extent of airway responsiveness at follow-up after percutaneous ASD closure.	—

Secondary

Measure	Time frame
Secondary ~: difference in airway responsiveness between pre-procedural and post-procedural measurements.	—

Countries

Netherlands

Outcome results