Epilepsy
Conditions
Interventions
The healthy subjects and the 20 patients without a VNS will be measured for
approximately one hour with the tVNS. Epilepsy patients with a VNS are measured
for approximately 20 minutes with a VNS.
(t)VNS
Epilepsy
Heart rate (variability)
Pupil diameter
Sponsors
Medisch Spectrum Twente
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria: - Age * 18 - physically and cognitively capable of using the tVNS device and participating in the measurement. - able to read and understand Dutch. ;For the 40 epilepsy patients there are more inclusion criteria. The 40 patients are subdivided in a patient group with a vagus nerve stimulator and a patient group without a vagus nerve stimulator. ;For the epilepsy patients without a VNS there are more inclusion criteria in addition to the general inclusion criteria: - diagnosed with epilepsy - the patients has no implanted VNS system;For the epilepsy patients with a VNS inclusion criteria are also: - diagnosed with epilepsy - implanted with a VNS system
Exclusion criteria
Exclusion criteria: - Severe cognitive impairment - History of cardiovascular disease - Presence of an eye disease - Eye surgery in the past - Implanted with a pacemaker - Diabetes - Use of beta blockers - Use of anticholinergic or psychostimulant medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the effect of tVNS stimulation on the pupil diameter, heart rate and heart rate variability. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is the effect of VNS stimulation on the pupil diameter and heart rate. | — |
Countries
The Netherlands
Outcome results
None listed