Renal transplant rejection
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Female or male aged between 18 and 80 years. • The patient understands the purpose and risks of the study and has given written informed consent to participate in the study. • All patients will have a clinical indication for renal biopsy.
Exclusion criteria
Exclusion criteria: • Patients with multiple-organ transplants. • Female patients who are pregnant or unwilling to use adequate contraception during the study. • Altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent. • A clinical reason for an immediate start of a therapeutic intervention with immunosuppressive medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uptake of [18F]FB-IL2 in the transplanted kidney will be correlated to inflammatory infiltrate and histological BANFF score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Uptake of [18F]FB-IL2 in the transplanted kidney will be correlated to renal function as measured by 24-hours urine clearance and MDRD. Uptake of [18F]FB-IL2 in the transplanted kidney will be correlated to T-cell subpopulations in urine and blood. Uptake of [18F]FB-IL2 in the transplanted kidney will be correlated to outcome after kSORT analysis in blood. | — |
Countries
Netherlands
Outcome results
None listed