acute myocardial infarction
Conditions
Interventions
None listed
Sponsors
Catharina-ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Patients with STEMI * 12 hours and with ST deviation * 5 mm. Who have one or more other lesions mandating FFR or PCI in de following days after PCI of the culprit artery;INCLUSION CRITERIA * Age between 18 and 75 years * Presentation within 12 hours after the onset of complaints * Acute ST-elevation myocardial infarction with a total ST segment deviation *5 mm * Able to give and understand informed consent * Culprit lesion in a proximal or mid-segment of one of the major coronary arteries (diameter *2,5 mm), which is stented successfully * Stable condition after stenting * One or more additional lesions in one or more different coronary arteries, mandating FFR measurement +/- PPCI during the subacute phase
Exclusion criteria
Exclusion criteria: * Age less than 18 years or more than 75 years * Cardiogenic shock or pre-shock * Patients with previous myocardial infarction in the culprit artery or with previous bypass surgery * Very tortuous or calcified coronary arteries * Long or complex PCI * Severe concomitant disease or conditions with a life expectancy of less than 1 year * Inability to understand and give informed consent * Known myocardial diseases such as moderate or severe left ventricular hypertrophy or cardiomyopathy * Pregnancy * Severe conduction disturbances necessitating implantation of a temporary pacemaker * Contraindications for MRI (claustrophobia, ferromagnetic metal fragments in the body)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate changes in myocardial resistance over time in STEMI patients, both in the early stage and the subacute phase. It is hypothesized that patients can be divided into 3 groups: A. Patients with an (almost) normal resistance and flow immediately after PPCI B. Patients with still elevated resistance and decreased flow immediately after PPCI, but (partial) recovery in the next days C. Patients with elevated resistance and decreased flow immediately after PPCI which do not recover at all. | — |
Secondary
| Measure | Time frame |
|---|---|
| The course of such changes and recovery of the microcirculation will be correlated to long-term outcome as assessed by MRI measurements and final infarct size 1) Long term outcome 2) final infarct size on MRI | — |
Countries
Netherlands
Outcome results
None listed