epilepsy epileptic seizures
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. All patients selected by the Dutch Collaborative Epilepsy Surgery Program board for the diagnostic work-up for the surgical treatment of refractory epilepsy and a suspected malformation of cortical development or cortical dysplasia as underlying cause, with and without presence of primary lesion (mesiotemporal sclerosis, glioneuronal tumor, vascular malformation or traumatic brain injury at young age). Also, in case of suspicion of focal epilepsy and negative clinical (3T) MRI 2. Prior clinical 1.5 or 3T MRI
Exclusion criteria
Exclusion criteria: 1. Age under 6 2. Mentally or physically incapable of giving consent (for age 12 years and up) 3.Insufficient understanding of Dutch written or spoken patient information (parent or legal guardian for patients under 12, both patient and parent or legal guardian for patients in the age 12-18) 4. Uncooperative during previous MRI scans 5. Contra-indications for 7 T MRI as specified by the UMCU radiology department at the time of inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Presence on 7T MRI and lower-field MRI of specific characteristics of FCD. Comparison of imaging characteristics on 3 and 7 T MRI. • Correlates between in-vivo and ex-vivo 7 T MRI characteristics and histopathological findings and quantifications in resected dysplastic tissues. • Histopathological diagnosis | — |
Secondary
| Measure | Time frame |
|---|---|
| • Seizure outcome • Seizure frequency • Semiology • Age of seizure onset • Abnormalities on PET • Abnormalities on SPECT • Abnormalities on MEG • Abnormalities on EEG • Abnormalities on Electrocorticography | — |
Countries
Netherlands
Outcome results
None listed