low platelet count Thrombocytopenia
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Patients need to be admitted to the Intensive Care Unit • The indication for 1 unit of PLT concentrate, at physician*s discretion. • Arterial line to enable blood sampling.
Exclusion criteria
Exclusion criteria: • Contra-indication for PLT transfusion, e.g. TTP. • The use of ticagrelor or clopidogrel. • Severe active bleeding, e.g. bleeding that leads to multiple transfusions. • No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The increase in platelet count and the effect on coagulation before and after platelet concentrate transfusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Platelet increment at 2 and 4 hours • Rotational tromboelastography (INTEM, EXTEM, FIBTEM) • MCF, CT, CFT, a-Angle. • Classical coagulation tests • PT, INR, aPTT • Fibrinogen • D-Dimer • Multiplate • AUC, slope. • Trombin-antitrombin complexes • Trombin generation • Endothelial activation • Syndecan • Fragmentocytes | — |
Countries
Netherlands
Outcome results
None listed