adenomas neoplasia polyps
Conditions
Interventions
None listed
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • HL diagnosis at the age of 16-50 years • Treatment for HL between 1965 and 2007 • Treatment of primary or recurrent HL consisting of o infradiaphragmatic radiotherapy (any field(s)) and chemotherapy (any regimen) and/or o infradiaphragmatic radiotherapy consisting of at least para-aortal and iliac fields and/or o chemotherapy containing a cumulative procarbazine dose of >=2.8 g/m2 (e.g. >=2 MOPP, >=4 BEACOPP or >=4 MOPP/ABV courses) • Survival of at least 8 years after the first treatment that included infradiaphragmatic radiotherapy and chemotherapy or procarbazine-containing chemotherapy • Age of 25 years or older • Life expectancy of five years or more
Exclusion criteria
Exclusion criteria: • Proctocolectomy • Colonoscopy surveillance for other indications (including hereditary CRC syndrome, familial CRC syndrome, inflammatory bowel disease, history of colorectal adenoma or CRC) • Colonoscopy in the past five years • On-going cytotoxic treatment or radiotherapy for malignant disease • Coagulopathy (prothrombin time 50 seconds) or anticoagulants (marcoumar, acenocoumarol or new oral anticoagulants) that cannot be stopped • Comorbidity leading to an impaired physical performance (World health organization (WHO) performance status 3-4) or mental retardation • No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Diagnostic yield of advanced colorectal neoplasia detected by a colonoscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| - Molecular characteristics of advanced colorectal neoplasia - The relation of neoplasia characteristics to radiotherapy and / or chemotherapy - The cost-effectiveness of colonoscopy screening - The burden of colonoscopy screening - Performance of fecal immunochemical test and molecular stool test - The development of CRC surveillance guidelines for HL survivors | — |
Countries
Netherlands
Outcome results
None listed