Stress-induced malodor formation Malodor Sweat odor
Conditions
Interventions
In order to expose subjects to external stressors that induce emotional stress
responses, they will be submitted to a cognitively and emotionally challenging
task: the adapted STMST. In the basic ST
Malodor
Skin microbiota
Stress
Sweat
Sponsors
Procter & Gamble
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Male 2. Age 18-34 yrs 3. BMI between 18,5-25 kg/m2 4. Healthy as assessed by the NIZO lifestyle and health questionnaire (*Verklaring leefgewoonten en gezondheid*). 5. Non-smoking 7. Access to internet
Exclusion criteria
Exclusion criteria: 1. Alcohol consumption > 15 units/week and > 3/day. 2. Drug abuse 3. Heavy exercise or sports training > 10 hours/week. 4. Hyperhidrosis , Hypohidrosis or Anhidrosis 5. Known allergy to cosmetics 6. Psychiatric disorders 7. Use of anti-anxiety medications or beta-blockers, statins or blood pressure medication 8. Use of antibiotics during the six (6) months prior to study start. 9. Use of topical medications in underarm area during two (2) weeks prior to study start 10. Active eczema or psoriasis on any portion of the body.;Procedural: 1. Personnel of the research institute(s) involved in execution of the study, their partner and their first and second degree relatives 2. Not having a general practitioner, not allowing disclosure of participation to the general practitioner or not allow to inform the general practitioner about abnormal results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is to assess whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce malodor formation by emotional stress, as assessed by expert assessments of stress-induced malodor formation in the armpits of healthy male volunteers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives: * To determine whether the adapted Sternberg short-term working memory task (STMST) is an effective and valid method to induce emotional stress, as assessed by measurable stress biomarkers (cortisol in saliva); * To determine whether the adapted Sternberg short-term working memory task (STMST) is an effective and valid method to induce emotional stress, as assessed by self-assessed mood state; * To explore the volatile malodor compounds formation during conditions of emotional sweating induced by the adapted STMST; * To explore the correlation between skin microbial species that are known to induce the formation of malodor components (i.e. Corynebacterium species, C. tuberculostearicum, C. jeikeium, C. mucifaciens, C. minutissimum, C. striatum, C. bovis, C. urealyticum, and Staphylococus species, S. epidermidis, S. haemolyticus, S. lugdunensis, S. hominis S. capitis, S. caprae) and the production of malodor components induced by the adapted STMST; * To explore the correlation between other relevant skin microbial species and the formation of malodor compounds induced by the adapted STMST; Tertiary objectives: * To explore the effects of the presence of microbial genes known to be involved in malodor formation on malodor compounds formation induced by the adapted STMST; * To explore the effects of the activity of genes known to be involved in malodor formation on malodor compounds formation induced by the adapted STMST. | — |
Countries
The Netherlands
Outcome results
None listed