Modulation of Electrical Brain Responses by Nociceptive Stimulus Properties and Stimulus Detection: an Exploratory Study

Modulation of Electrical Brain Responses by Nociceptive Stimulus Properties and Stimulus Detection: an Exploratory Study - Modulation of Electrical Brain Responses by Nociceptive Stimulus Properties

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44357

Enrollment

Registered

2017-11-10

Start date

2017-11-21

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(chronische) pijn, perifere sensitisatie, centrale sensitisatie pain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 40 years old.

Exclusion criteria

Exclusion criteria: * Participant refusal during the study. * Language problems. * Skin problems at site of stimulation or EEG recording. * Diabetes. * Implanted stimulation device. * Pregnancy. * Usage of analgesics within 24 hours before the experiment. * Consumption of alcohol or drugs within 24 hours before the experiment. * Pain complaints at the time of the experiment. * A medical history of chronic pain.

Design outcomes

Primary

Measure	Time frame
Several types of nociceptive stimuli will be applied, while the subject*s response (detected or not detected) and the stimulus related EEG epochs will be measured. This data will be used for computation of a linear mixed-model describing the influence of stimulus parameters on the nociceptive evoked potential.	—

Secondary

Measure	Time frame
Analysis to determine if and how the EEG signal is dependent on stimulus properties like the inter-pulse interval, stimulus amplitude and stimulus detection.	—

Countries

Netherlands

Outcome results