total parenteral nutritrion
Conditions
Interventions
Subjects will undergo an enteral and a parenteral mixed meal test (MMTs) on
different days in random order. The mixed meal test will be performed using
Olimel Perifeer N4E (Baxter B.V. Utrecht, The
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Ability to provide informed consent - 18 years or older at the time of signing the informed consent - Body mass index (BMI) 18.5- 25 kg/m2 - Caucasian men - General good health as determined by medical history, physical examination and blood chemistry by a physician. -HOMA-IR index: * 2.0 (measured as fasting insulin (pmol/L) x fasting glucose (mmol/L) / 135)
Exclusion criteria
Exclusion criteria: -Major illness in the past 3 months -Use of any medication -Gastro-intestinal disease that may influence bile acid metabolism -History of cholecystectomy or other bile duct abnormalities -Tobacco smoking -Drugs abuse -Alcoholism (>3 units a day) -Allergy or intolerance to ingredients included in the standardized meals -Blood chemistry: *Creatinine >120 µM *>2 times upper limit reference interval of the following: ASAT, ALAT, bilirubin, GGT and AF. *Lipid spectrum -Strenuous exercise for at least 3 days prior to each study day, defined as more than 1 hour of exercise per day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of a parenteral MMT compared to an enteral MMT on * Postprandial bile acid signalling metabolism * Postprandial inflammatory responses | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the effect of a parenteral MMT compared to an enteral MMT on * Glucoregulatory and gut hormones * Lipid profiles * Resting energy expenditure * Appetite and satiety * Blood pressure * Body core temperature 2. Assess the correlation between the microbiota composition and postprandial bile acid signalling. | — |
Countries
Netherlands
Outcome results
None listed