no health condition is addressed in the research, and healthy volunteers who are occasional MDMA users will be recruited n.a.
Conditions
Interventions
Placebo (bitter lemon drink) and MDMA (75mg capsules dissolved in bitter lemon
drink)
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers who have experience with the use of ecstasy/MDMA (maximally 200 times in total, minimally 3 times in total; and at least once in the past 12 months): This will be assessed by means of a drug history questionnaire and an interview by the medical supervisor Age between 18 and 40 years Good physical health as determined by medical examination and laboratory analysis Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 Written Informed Consent Good knowledge and understanding of the English language (at least 5 years of English language education* assessed in the prescreening)
Exclusion criteria
Exclusion criteria: History of drug abuse (other than the use of MDMA) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination) Pregnancy or lactation (pregnancy test, if needed) Use of psychotropic medication (i.e. medication prescribed by a physician) Any major medical, endocrine and neurological condition] Decreased liver function Hypertension (diastolic> 90; systolic> 140) Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) Liver dysfunction (Serious) side effects due to previous MDMA consumption History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)/ cardiovascular abnormalities as indicated by (1) The medical questionnaire and/or (2) the standard 12-lead ECG Previous participation in study NL60303.068.16, *Acute and delayed effects of THC intoxication on false memories in a legal context*
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary: Spontaneous false memories will be measured using the Deese/Roediger-McDermott (DRM) paradigm. Suggestion-based false memories will be assessed via exposing subjects to a virtual reality mock crime and adding suggestive misinformation in subsequent interrogations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary: Dissociative psychopathology (i.e., dissociative traits) will be measured using the Dissociative Experiences Scale (DES). Reality monitoring/dissociative symptoms (i.e., dissociative states) will be assessed using the Clinician Administered Dissociative States Scale (CADSS). Other parameters include constructs related to (false) memory, such as attention, information processing, compliance, arousal, and convergent and divergent thinking. | — |
Countries
Netherlands
Outcome results
None listed