Objective home-based bradykinesia assessment in Parkinson*s disease - a pilot study

Objective home-based bradykinesia assessment in Parkinson*s disease - a pilot study - Objective bradykinesia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44312

Enrollment

Registered

2018-06-12

Start date

2018-08-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for Parkinson's disease and Cerebellar Ataxia only: (1) confirmed idiopathic Parkinson's Disease or Cerebellar Ataxia and (2) presence of slowness of movement. Inclusion criteria for all participants are: (1) usage of a computer with a QWERTY keyboard; (2) 18 years or older at the time of the recruitment; (3) no signs of depression or cognitive impairment; (4) no untreated hearing, visual or upper limb impairment; and (5) ability to provide written informed consent.

Exclusion criteria

Exclusion criteria: The exclusion criteria for healthy elderly is: self-reported history of neurologic disease. For Parkinson's disease and Cerebellar Ataxic patients exclusion criteria are: self-reported incapacitating tremor, dystonia or dyskinesia, and an irregular medication intake scheme.

Design outcomes

Primary

Measure	Time frame
The analyses of the usual typing behaviour will provide two outcomes: typing cadence and inconsistence in typing cadence. Discriminative function analysis will evaluate the predictive power of the free typing behaviour to distinguish between Parkinson's Disease patients, Ataxic patients and healthy controls. Correlations between 1 - typing cadence or 2 - inconsistence in typing cadence with validated assessments will be used to determine the validity of typing cadence in determining the severity of bradykinesia in akinetic patients.	—

Measure

Time frame

The analyses of the usual typing behaviour will provide two outcomes: typing cadence and inconsistence in typing cadence. Discriminative function analysis will evaluate the predictive power of the free typing behaviour to distinguish between Parkinson's Disease patients, Ataxic patients and healthy controls. Correlations between 1 - typing cadence or 2 - inconsistence in typing cadence with validated assessments will be used to determine the validity of typing cadence in determining the severity of bradykinesia in akinetic patients.

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Secondary

Measure	Time frame
This study has one secondary study parameter: the sequence effect. The sequence effect will be expressed by the sum of keys pressed by the most affected hand per each second of the test. Sequence effect in the dominant hand will also be investigated. Furthermore, sequence effect will also be calculated from the video recording. The intensity of sound will be used to calculate amplitude and frequency of movement.	—

Measure

Time frame

This study has one secondary study parameter: the sequence effect. The sequence effect will be expressed by the sum of keys pressed by the most affected hand per each second of the test. Sequence effect in the dominant hand will also be investigated. Furthermore, sequence effect will also be calculated from the video recording. The intensity of sound will be used to calculate amplitude and frequency of movement.

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Countries

Netherlands

Outcome results