Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients

Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients - Multiple Sclerosis Family Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44305

Enrollment

100

Registered

2017-09-11

Start date

2017-08-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

demyelinating disease multiple sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For patients with MS: They must have been diagnosed with MS for at least one year. They must be able and willing to participate in the study. They must be at least 18 years old. They must have at least one relative diagnosed with MS from another generation, and who meets the inclusion criteria. They must have at least two healthy control relatives whom are willing and able to participate in this study.;For healthy control family members (siblings, cousins, (grand)parents and aunts/uncles): They must be able and willing to participate in the study. They must be at least 20 years old

Exclusion criteria

Exclusion criteria: Not applicable.

Design outcomes

Primary

Measure	Time frame
The occurrence of de novo/rare variants in genetic data of familial MS cases.	—

Secondary

Measure	Time frame
Phenotypic data in a family that could be related to the genetic/biological data.	—

Countries

Netherlands

Outcome results