eigenschappen van vetweefsel (dys)function adipose tissue fat tissue characteristics
Conditions
Interventions
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patient undergoing bariatric surgery (BMI above 35) Age above 40
Exclusion criteria
Exclusion criteria: taking 2 or more antihypertensiva taking metformine for diabetes heart diseases, for example myocardinfarct in past
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints * AT mass, distribution and ratios (EAT, PAT,VAT) * Circulating AT derived protein biomarkers, including: (1) inflammatory markers, (2) adipocytokines, (3) oxidative stress markers, (4) growth and remodelling markers, (5) markers representing AT metabolism. * Circulating AT derived miRNAs * Locally AT derived protein biomarkers, extracted from VAT. Markers similar to those in circulation. * Locally AT derived miRNAs extracted from VAT. * Anthropometric measurements: height, weight, BMI, waist-circumference, hip-waist ratio. * Occurrence/absence of AF by an approved 7 days rhythm monitoring system. * 1. Questionnaire about food and calorie intake: Diet journal for one week using an Internet application (Eetmeter, Stichting Voedingscentrum Nederland, The Hague, Netherlands). * 1. EPIC Norfolk Food Frequency Intake Questionnaire * 2. International Physical Activity Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical data: data is gathered on the patients history and medication use and AF associated factors such as coronary artery disease, gender, age, hypertension, medication use and response, smoking, BMI, kidney function and laboratory parameters. | — |
Countries
The Netherlands
Outcome results
None listed