arterial wall thickening atherosclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients - Aged 18 years or older - Diagnosed with diabetes mellitus type 2 ;Control subjects - Age 18 years or older - No history of diabetes mellitus or impaired glucose tolerance - No history of cardiovascular events - No medication use
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects - Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. - Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. - History of cardiovascular event within the last 3 months. - Clinical signs of acute infection and/or CRP > 10 mg/L. - The use of chronic immunosuppressant drugs or antibiotics in the last 6 weeks. - Chronic use of anti-inflammatory drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare monocyte expression of pro-atherogenic markers, cytokine production, epigenetic changes and trans-endothelial migration between diabetes patients and controls, and asses differences between patient groups. Furthermore, changes in these parameters after ex vivo incubation with stimuli and current and novel anti-inflammatory therapies will be assessed. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed