Discordant Monozygotic Twinning in Beckwith-Wiedemann Syndrome: A Study of Embryonic Pluripotency and Epigenetic Reprogramming

Discordant Monozygotic Twinning in Beckwith-Wiedemann Syndrome: A Study of Embryonic Pluripotency and Epigenetic Reprogramming - Discordant MZ Twins with BWS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44262

Enrollment

Registered

2017-09-05

Start date

2018-02-08

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beckwith-Wiedemann Syndrome

Interventions

Beckwith- Wiedemann Syndrome

epigenetics

iPSC

monozygotic

Eligibility

Age

2 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1) Monozygotic twins 2) Discordant for Beckwith-Wiedemann syndrome 3) BWS clinical diagnosis molecularly confirmed 4) Able and willing to provide written informed consent to the study

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
The molecular and phenotypic differences of naïve and primed iPSCs obtained from discordant BWS MZ twins.	—

Secondary

Measure	Time frame
Obtaining insight in the mechanism behind the splitting of the ICM for the birth of identical twins, which will have direct relevance to the study of embryonic pluripotency.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)