Ataxia telangiectasia (AT)
Conditions
Interventions
Ataxia Telangiectasia
Chronic lung disease
Magnetic Resonance Imaging
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: Part 1: Patients with chronic lung diseases other than AT: These are patients with a chronic lung disease (such as bronchiectasis, or Cystic Fibrosis) for whom a routine CT * scan of the lungs is planned as part of routine patient care, for their follow-up and treatment of their illness. In addition to the CT-scan these patients (children and adults) will be asked to participate by obtaining MRI imaging of the lungs. Children from the age of 6 years on will be recruited. Part 2: During this part of the study, MRI images will be obtained in patients with AT. Special attention will be payed to correcting for moving artefacts, and to optimization of the resolution of the technique. Subjects who are quite young and/or uncomfortable in a tunnel will be trained using our *dummy MRI*, that is available near the Radiology Department. In those children, a simulation MRI investigation will be tested and conducted by specialized nurses. From the second year on, we will start investigate children and adults with AT using MRI.
Exclusion criteria
Exclusion criteria: The usual general exclusion criteria for MRI investigations in clinical practice, including claustrofobia. Extreme fatigue in AT patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study result/product will be a reliable and useful imaging technique of the lungs without having to use ionising radiation in AT patients. This will be scored by two experienced radiologists. The main quality criteria are the ability to detect: * Bronchiectasis * Atelectasis and/or consolidation * Emphysema * Other lungabnormalities | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
The Netherlands
Outcome results
None listed