Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency.

Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency. - KLOGIC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44245

Enrollment

Registered

2014-09-12

Start date

2015-05-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Klotho levels in isolated growth hormone deficiency

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: - Subjects with newly diagnosed GHD according to the guideline *Guideline for GH treatment in children* with an indication for treatment with rhGH . - Boys

Exclusion criteria

Exclusion criteria: - Subjects with a combined pituitary hormone deficiency. - Patients taking medications or having concomitant illnesses likely to confound endpoint assessments (e.g.use of corticosteroids, androgens or anabole steroids, insulin). - Patients with hypothyroidism not adequately supplied with thyroid hormone. - Patients taking other experimental (i.e., non marketed) therapies. - Patients with any kind of kidney disease. - Patients with a single kidney.

Design outcomes

Primary

Measure	Time frame
The absolute change in sKlotho levels in serum and urine before and after treatment with rhGH in paediatric patients with IGHD.	—

Secondary

Measure	Time frame
not applicable.	—

Countries

Netherlands

Outcome results