neonatale immuunontwikkeling immunsuppressive therapy during pregnancy
Conditions
Interventions
None listed
Sponsors
Kindergeneeskunde, Radboudumc
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy pregnant women aged 18-40 years.;Kidney transplant >1 year before pregnancy Stable kidney function glomerular filtration rate of >30ml/min/1.73m2
Exclusion criteria
Exclusion criteria: Healthy: Use of immunosuppressive drugs, biological or antidepressants HIV positivity Active infection during caesarean section o Signs of infection (maternal fever or signs of intrauterine infection) o Use of antibiotics prior to caesarean section;Patients Use of other medication (biologicals or antidepressants) besides immunosuppressive medication HIV positivity Active infection during delivery o Signs of infection (maternal fever or signs of intrauterine infection) o Use of antibiotics prior to caesarean section
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells. 2. To investigate the neonatal immune response against a variety of pathogens and compare this with the adult immune response | — |
Countries
Netherlands
Outcome results
None listed