Optical coherence tomography (OTC) in the follow-up of patients with X-linked adrenoleukodystrophy (X-ALD) and Zellweger spectrum disorders (ZSD).

Optical coherence tomography (OTC) in the follow-up of patients with X-linked adrenoleukodystrophy (X-ALD) and Zellweger spectrum disorders (ZSD). - OCT for X-ALD and ZS.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44231

Enrollment

230

Registered

2015-02-16

Start date

2015-05-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schilder's disease X-ALD X-linked adrenoleukodystrophy

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: 1. Established diagnosis of X-ALD or ZSD (either biochemically and/or genetically). 2. Must be able to undergo ophthalmological examination and optical coherence tomography, i.e. must be able to follow instructions and not move for several minutes.;Subjects eligible to participate as healthy controls must meet all of the following criteria: 1. Willing to visit the hospital* 2. 12 years or older 3. Informed consent obtained from participant* 4. Informed consent obtained from participant or legal guardian in case of a minor

Exclusion criteria

Exclusion criteria: Patient or control: 1. Pre-existing eye disease that creates confounders in interpretation of OCT measurements 2. Unable to follow instructions, which makes ophtalmological examination and OCT impossible (e.g. age or mental retardation)

Design outcomes

Primary

Measure	Time frame
OCT parameters (i.e. RNFL, GCL en IPL).	—

Secondary

Measure	Time frame
Neurologic examination, SF-36, EDSS, ALDS.	—

Countries

Netherlands

Outcome results