biased cognition selective attention
Conditions
Interventions
Participants will receive either a placebo or 40 mg of hydrocortisone as
capsules for oral intake, in the afternoon after limited dietary restrictions
(no intake of nutrients 1.5 hour prior to drug/
cognitive performance
cortisol
emotion
stress
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: good physical health 17
Exclusion criteria
Exclusion criteria: -use of prescription medication -history of psychiatric, neurologic, or endocrine illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance (measured response times and accuracy scores) on various computerized tasks that measure attentional processing of emotional stimuli and executive cognitive performance. Also, self-reported cognitive interference during cognitive performance will be assessed. Finally, we will Assess resting-state EEG, salivary cortisol concentration, several self-reported psychological trait questionnaires and self-reported state anxiety and state attentional control. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary aim, we will examine whether the effects of hydrocortisone on cognition are moderated by frontal EEG theta/beta ratio (or other trait characteristics such as trait attentional control as assessed by the ACS). In order to test this hypotheses, mixed ANCOVAs will be performed with the same between and within-subjects factors, as described in section 10.1, and theta/beta ratio (or ACS) as covariate (s). If applicable, follow-up simple slope analyses will be performed to reveal the nature of significant moderational interactions. The negative relationship between theta/beta ratio and attentional control will be tested with Pearson's correlations and partial correlations, controlling for trait anxiety. | — |
Countries
The Netherlands
Outcome results
None listed