Cerebral small vessel diseases (SVDs) op basis van Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
Conditions
Interventions
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Symptomatic SVD defined as a diagnosis of CADASIL * Age 18 years or older * Capacity to give written informed consent * Independent in activities of daily living (Modified Rankin score * 3)
Exclusion criteria
Exclusion criteria: * Inclusion criteria are not met * Unwillingness or inability to give written consent * Pregnant women, women of childbearing age not taking contraception * Contraindications to MRI * Other major neurological or psychiatric conditions affecting the brain and interfering with the study design * In case of clinical lacunar stroke syndrome other causes of stroke dan small vessel disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measures of microvascular function at 7T MRI: - Difference in mean velocity and pulsatility index of perforator flow between patients and controls. - Difference in time course of the BOLD-fMRI signal to a visual stimulus in different cortical layers between patients and controls. - Difference in Cerebrovascular reactivity (CVR) to a hypercapnic stimulus between patients and controls. | — |
Countries
The Netherlands
Outcome results
None listed