ChanGes In Right ventricular volumes And Function Following diurEtic Treatment In Pulmonary arterial hypertension patients with decompensated right heart failure (GIRAFFE)

ChanGes In Right ventricular volumes And Function Following diurEtic Treatment In Pulmonary arterial hypertension patients with decompensated right heart failure (GIRAFFE) - Changes in right ventricular volumes and function

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44204

Enrollment

Registered

2017-11-14

Start date

2018-02-27

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary hypertension right heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of idiopathic PAH, hereditary PAH, drug- and toxins induced PAH or chronic thrombo-embolic PH (CTEPH), according to ESC/ERS pulmonary hypertension guidelines (15) - Symptoms of decompensated right heart failure (ankle edema, ascites, weight gain) based on the assessment and the evaluation of the pulmonologist for which an up-titration of the diuretics is indicated - Age >=18 and

Exclusion criteria

Exclusion criteria: - Pregnant subjects - Claustrophobia - Inability to provide informed consent - Change in PAH specific therapy during or the 3 months before the up-titration of diuretics - Change in (dose) of any other medication. - One or more of the following co-morbidities:, uncontrolled systemic hypertension (>140/90 mmHg) , renal failure (eGFR

Design outcomes

Primary

Measure	Time frame
Change in stroke volume (SV) , Change in right ventricular ejection fraction (RVEF) (%), Change in right ventricular end diastolic volume (RVEDV) (ml), Change in right ventricular end systolic volume (RVESV) (ml), Change in right atrial pressure (RAP),volume, Change in right ventricular strain.	—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results