Obesitas fullness satiety
Conditions
Interventions
During two study visits the subjects will receive 200mL lactase-containing milk
with either 15 g casein protein or 15 g whey protein as supplement in a blinded
randomized order.
Sponsors
Medisch Centrum Leeuwarden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Female Gastric bypass surgery at age 18-65 years Primary gastric bypass between 12 and 18 months ago
Exclusion criteria
Exclusion criteria: Follow-up is not feasible Known allergies or intolerance to ingredients used in the intervention product Medicine usage known to influence dietary uptake and/or appetite Pregnancy Hypo- or hyperthyroidism Known malabsorption syndrome Known heart failure Known renal insufficiency or failure Known severe hepatic disease Known severe symptomatic post gastric bypass hypoglycaemia Active Diabetes Mellitus or remission Former gastric operations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To assess and compare the net incremental area under the curve of satiety-related plasma amino acids and derivatives (i.e. Alanine, Arginine, Asparagine, Glutamine, Glycine, Histidine, Lysine, Phenylalanine, Serine, Taurine, Threonine, a-aminobutyric acid) in response to lactase-containing milk supplemented with either casein or whey protein in a randomized controlled cross over study in subjects 12-18 months after primary gastric bypass surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To assess and compare the effect of the ingestion of both protein supplements in lactase-containing milk on plasma concentrations of all amino acids and derivatives, plasma concentrations of anorexigenic gastrointestinal hormones PYY and GLP-1, satiety, hunger, dumping symptoms, heart rate, blood pressure, glucose metabolism and ad libitum food intake after completion of the test meal in a randomized controlled cross over study in subjects 12-18 months after primary gastric bypass surgery. - To assess the self-reported dietary patterns, macronutrient consumption, energy intake, eating behaviour and physical activity measured by questionnaires in subjects 12-18 months after primary gastric bypass surgery. | — |
Countries
Netherlands
Outcome results
None listed