Calibration of non-invasive measurement of mitochondrial oxygenation in healthy volunteers

Calibration of non-invasive measurement of mitochondrial oxygenation in healthy volunteers - cal-MitoPO2

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44178

Enrollment

Registered

2018-01-15

Start date

2018-06-21

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxygenatie Human measurement technique calibration

Interventions

ALA plaster Pp-IX accumulation in the skin. This enables the mitochondrial oxygen tension measurement. Mitochondrial respiration inhibition cream to make the oxygen tension the cells temporary equa

Mitochondria

Oxygen

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy volunteer

Exclusion criteria

Exclusion criteria: Mentally disabled Presence of mitochondrial disease Diabetic Other deceases that may influence the mitoPO2 such as: Anemia Hemoglobinopathy mild COPD Porphyria Positive Modified Allen Test: ulnar arterial flow in the hand is insufficient

Design outcomes

Primary

Measure	Time frame
Pp-IX lifetime	—

Secondary

Measure	Time frame
Bloedgas analysis Mitochondrial respiration Temperature Demografic data Microvasculair data (flow and saturation) Bloodpressure and heartfrequency	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)