The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis

The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis - PERIO-IIM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44156

Enrollment

Registered

2017-10-10

Start date

2018-01-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parodontitis Gum disease

Interventions

Atherosclerosis

Inflammation

Periodontitis

Trained innate immunity

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Age between 40 and 80 years - With or without severe periodontitis with DPSI score of 0-2 resp. 4 - Written informed consent

Exclusion criteria

Exclusion criteria: - Cardiovascular events - Diabetes mellitus - Chronic infections other than periodontitis - Medical history of any disease associated with immune deficiency (either congenital or acquired, including chemotherapy, chronic steroid use, organ transplant) - Fever (T > 38.5) or antibiotics use for infectious disease within 1 month prior study entry - Chronic use of anti-inflammatory drugs such as NSAIDs - Recent hospital admission or surgery with general anaesthesia (

Design outcomes

Primary

Measure	Time frame
The main study parameter will be to correlate tissue inflammation, measured by TBR max with 18F-FDG on PET-CT scanning of periodontal tissue with the vascular wall, spleen and bone marrow in patients with versus without periodontal disease.	—

Secondary

Measure	Time frame
The cytokine/chemokine response to ex vivo stimulation of the innate immune cells in patients with versus without periodontal disease.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)