Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Each subject will consume (in a randomized fashion) both the intervention
beverage (NaNO3 solution: 7x ~140 mL
7x ~8 mmol NO3-1)) and the placebo (NaCl
solution: 7x ~140 mL), separated by a 1 wk washout period.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. 2) Peak VO2 / peak load > 10 ml/min/W, as a indication for metabolic inefficiency, determined using CPET data available from the assessment.
Exclusion criteria
Exclusion criteria: - Sodium intake limitation - Long-term oxygen therapy, because of the methodology that is used to measure oxygen uptake and ventilation - Severe renal impairment (GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter is metabolic efficiency during submaximal cycle ergometry tests (before and after 7 days of ingestion of both NaNO3 solution and NaCl placebo). Metabolic efficiency will be calculated with the following equation: Metabolic efficiency = (load (W) of exercise * 0.01433 (kcal*min-1) / (energy expenditure during exercise * REE)(kcal*min-1)*100% | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are bloodpressure, dyspnea, cycle endurance time, Oxygen uptake during rest and exercise, body temperature, blood markers (e.g. lactate, IFABP as a marker for intestinal damage and cardiac troponin as a marker for myocardial injury) . These parameters will be measured at 4 times (before and after 7 days of ingestion of both NaNO3 solution and NaCl placebo). | — |
Countries
Netherlands
Outcome results
None listed