seksuele (dis)functie(s) Mayer-Rokitansku-Kuster-Hauser syndrome Mullerian agenesis syndrome
Conditions
Interventions
MRKH syndrome
sexual arousal response
sexual functioning
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: All participants must have a sexual relation with a male partner for at least six months. Furthermore, Part 1, questionnaire study: All MRKH women with a neovagina, surgically as well as non surgically created, are invited. Control women are healthy females without the condition, age-matched with the study population. Via these women their partners are asked to participate. Part 2: psychophysiological assessment: Those MRKH as well as control women, participants of part 1 of the study, and aged between 18-45 years old.
Exclusion criteria
Exclusion criteria: For part 1 & 2: unable to speak, understand and write the Dutch language pregnancy or lactation (control women only);Only for part 2 * the depth of the neovagina is too small to carry the probe for the photoplethysmographic device ( MRKH women only) * having a disease that is known to affect genital response (such as Diabetes Mellitus, Multiple Sclerosis, Radical hysterectomy). * current use or recent use (less than 4 weeks before participation) of medication that may affect genital responses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1 Sexual functioning within a heterosexual relationship, measured with validated questionnaires ( * * Female sexual function index (FSFI), Female sexual distress scale (FSDS), ; **International Index of erectile function (IIEF), Male sexual distress scale (MSDS)). Part 2 Genital sexual arousal, measured with vaginal photoplethysmography that assesses changes in vaginal pulse amplitude (VPA), reflecting the phasic changes in vaginal engorgement during an experimental session; subjective sexual arousal measured through self-reported ratings of sexual arousal collected after the neutral and the erotic stimuli; | — |
Secondary
| Measure | Time frame |
|---|---|
| Part 1: Sexual self image measured with the Rosenberg*s Self Esteem Scale (RSES), Sexual Esteem Scale (SES) and Female Genital Self-image Scale (FGSIS) (only for * *) . Psychological functioning assessed with the Symptom Checklist (SCL)-90 and Hospital Anxiety and Depression Scale (HADS) ( for * * and **). Relational functioning by assessment of relationship satisfaction using the Maudsley Marital Questionniare (MMQ) ( for * * and **). Evaluation of an association between sexual functioning of MRKH women and these secundary outcome variables Part 2: Evaluation of a possible association between the kind of treatment ( surigal versus non surgical) and changes in vaginal blood flow; an association between the kind of surgery and vaginal blood flow responses will be examined exploratorily. | — |
Countries
The Netherlands
Outcome results
None listed